I've always been a two blade guy. I've killed many animals with 3,4,5 and even 6 blade heads but always go back to the two blade and now pretty much only shoot the two blade Buzzcut 125. I have never had an issue with getting good blood with a smooth edge but do see better cutting of structures inside the animal with the serration of the Buzzcut and thats the sources for blood and venting.
High hits are going to reduce blood no matter what the head and location is really the most important. From my experience most people shoot deer to far back and are out of most good sources for blood.